The news page highlights new features, versions, or other major announcements. See our changelog for all changes to gnomAD, including minor ones.
Today, we released gnomAD v4.1.1, which includes an update to our gene constraint metrics, LOFTEE flags, and a minor update to other flags and annotations. In this blog post, we discuss the improvements incorporated in this release, our new LOEUF threshold recommendations, and guidance around interpretation of the gene constraint metrics.
Thank you to everyone who completed the 2024 gnomAD user survey. Your feedback is invaluable in helping us improve gnomAD for all users. In…
We have released a new utility, the gnomAD toolbox, to enable easier analysis of gnomAD data. Community feedback has highlighted challenges…
We have now released an extension of local ancestry-informed frequency work from the inferred Admixed American genetic ancestry group to the inferred African/African American genetic ancestry group (n=20,805) within gnomAD v4.0. This implementation of local ancestry inference (LAI) resolves the admixed ancestries of African/African American samples into their respective African and European haplotypes, leading to better-informed functional and/or clinical classifications.
We have released gnomAD v4.1, an update to our latest major release. This update fixes the allele number issue in gnomAD v4.0 previously…
We updated our gene constraint metrics following the release of gnomAD v4.0. gnomAD v4.0 expanded the scale of our constraint calculations…
Today, we are delighted to announce the release of gnomAD v4, which includes data from 807,162 total individuals. This release is nearly 5x…
A critical component to the medical and functional interpretation of genetic variants involves the accurate estimation of their frequency. A…
Today, we are thrilled to announce the release of genome-wide structural variants (SVs) for 63,046 unrelated samples with genome sequencing…
We have expanded our representation of gnomAD v4 data to include data specifications from the Genomic Knowledge Standards Work…
In this minor release of gnomAD v3.1, we include the following improvements to the previous release: a fix to the homozygous alternate allele depletion adjustment that was made for v3.1 and several updates to the gnomAD v3.1 Human Genome Diversity Project (HGDP) and 1000 Genomes (1KG) subset release.