The news page highlights new features, versions, or other major announcements. See our changelog for all changes to gnomAD, including minor ones.
We have now released an extension of local ancestry-informed frequency work from the inferred Admixed American genetic ancestry group to the inferred African/African American genetic ancestry group (n=20,805) within gnomAD v4.0. This implementation of local ancestry inference (LAI) resolves the admixed ancestries of African/African American samples into their respective African and European haplotypes, leading to better-informed functional and/or clinical classifications.
We are happy to share, for the first time, local ancestry-informed frequency data for 14,804,207 bi-allelic SNPs within the Latino/Admixed American sample of gnomAD v3.1 (n=7,612). This initial release of gnomAD local ancestry inference (LAI) data contains estimated alternate allele counts, allele numbers, and allele frequencies partitioned by continental ancestries for variants in the Latino/Admixed American population. The samples classified as Latino/Admixed American by gnomAD’s global ancestry inference have highly heterogeneous, admixed ancestry,1 and local ancestry inference resolves these individuals’ admixed ancestry into Amerindigenous, African, and European haplotypes.